|Other Names||Nyctalopin, NYX, CLRP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in kidney and retina. Also at low levels in brain, testis and muscle. Within the retina, expressed in the inner segment of photoreceptors, outer and inner nuclear layers and the ganglion cell layer.|
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Provided below are standard protocols that you may find useful for product applications.
The product of this gene belongs to the small leucine-rich proteoglycan (SLRP) family of proteins. Defects in this gene are the cause of congenital stationary night blindness type 1 (CSNB1), also called X-linked congenital stationary night blindness (XLCSNB). CSNB1 is a rare inherited retinal disorder characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. The role of other SLRP proteins suggests that mutations in this gene disrupt developing retinal interconnections involving the ON-bipolar cells, leading to the visual losses seen in patients with complete CSNB. [provided by RefSeq].
??eroy, B.P., et al. Br J Ophthalmol 93(5):692-696(2009)??hang, Q., et al. Mol. Vis. 13, 330-336 (2007) ??organs, C.W., et al. Eur. J. Neurosci. 23(5):1163-1171(2006)??iao, X., et al. J. Hum. Genet. 51(7):634-640(2006)
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