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LDHA Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P00338 |
|---|
| Gene ID | 3939 |
|---|---|
| Other Names | L-lactate dehydrogenase A chain, LDH-A, Cell proliferation-inducing gene 19 protein, LDH muscle subunit, LDH-M, Renal carcinoma antigen NY-REN-59, LDHA |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LDHA (HGNC:6535) |
|---|---|
| Function | Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Predominantly expressed in anaerobic tissues such as skeletal muscle and liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
LDHA catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria.
References
Zhu, X., et al. Genet. Epidemiol. 34(2):171-187(2010) Zhuang, L., et al. Mod. Pathol. 23(1):45-53(2010) Zhao, Y.H., et al. Oncogene 28(42):3689-3701(2009) Xie, H., et al. Mol. Cancer Ther. 8(3):626-635(2009) Koukourakis, M.I., et al. Oncology 77(5):285-292(2009) Rikova, K., et al. Cell 131(6):1190-1203(2007) Rush, J., et al. Nat. Biotechnol. 23(1):94-101(2005)
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