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>   home   >   Products   >   Peptides   >   Blocking Peptides   >   TNFRSF10D Antibody (Center) Blocking Peptide   

TNFRSF10D Antibody (Center) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9UBN6
Additional Information
Other Names Tumor necrosis factor receptor superfamily member 10D, Decoy receptor 2, DcR2, TNF-related apoptosis-inducing ligand receptor 4, TRAIL receptor 4, TRAIL-R4, TRAIL receptor with a truncated death domain, CD264, TNFRSF10D, DCR2, TRAILR4, TRUNDD
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Function Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
Cellular Location Membrane; Single-pass type I membrane protein.
Tissue Location Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart EMBL; AF029761; AAD03477.1; -; mRNA EMBL; AF021232; AAC32765.1; -; mRNA EMBL; AF021233; AAC32766.1; -; mRNA EMBL; AF023849; AAC52053.1; -; mRNA EMBL; AY358285; AAQ88652.1; -; mRNA EMBL; AK313528; BAG36307.1; -; mRNA EMBL; BC052270; AAH52270.1; -; mRNA CCDS; CCDS6038.1; - RefSeq; NP_003831.2; NM_003840.4 SMR; Q9UBN6; - BioGRID; 114321; 7 DIP; DIP-6231N; - IntAct; Q9UBN6; 27 MINT; Q9UBN6; - STRING; 9606.ENSP00000310263; - iPTMnet; Q9UBN6; - PhosphoSitePlus; Q9UBN6; - SwissPalm; Q9UBN6; - BioMuta; TNFRSF10D; - DMDM; 18203495; - EPD; Q9UBN6; - MassIVE; Q9UBN6; - MaxQB; Q9UBN6; - PaxDb; Q9UBN6; - PeptideAtlas; Q9UBN6; - PRIDE; Q9UBN6; - ProteomicsDB; 84018; - Antibodypedia; 9716; 732 antibodies DNASU; 8793; - Ensembl; ENST00000312584; ENSP00000310263; ENSG00000173530 GeneID; 8793; - KEGG; hsa:8793; - UCSC; uc003xcz.4; human CTD; 8793; - DisGeNET; 8793; - EuPathDB; HostDB:ENSG00000173530.5; - GeneCards; TNFRSF10D; - HGNC; HGNC:11907; TNFRSF10D HPA; ENSG00000173530; Low tissue specificity MIM; 603614; gene neXtProt; NX_Q9UBN6; - PharmGKB; PA36600; - eggNOG; ENOG410IZX0; Eukaryota eggNOG; ENOG4111ZZM; LUCA HOGENOM; CLU_038161_0_0_1; - InParanoid; Q9UBN6; - KO; K22702; - OrthoDB; 1448442at2759; - PhylomeDB; Q9UBN6; - TreeFam; TF333916; - Reactome; R-HSA-202733; Cell surface interactions at the vascular wall Reactome; R-HSA-6803211; TP53 Regulates Transcription of Death Receptors and Ligands Reactome; R-HSA-75158; TRAIL signaling SignaLink; Q9UBN6; - SIGNOR; Q9UBN6; - BioGRID-ORCS; 8793; 0 hits in 785 CRISPR screens ChiTaRS; TNFRSF10D; human GeneWiki; TNFRSF10D; - GenomeRNAi; 8793; - Pharos; Q9UBN6; Tbio PRO; PR:Q9UBN6; - Proteomes; UP000005640; Chromosome 8 RNAct; Q9UBN6; protein Bgee; ENSG00000173530; Expressed in cartilage tissue and 158 other tissues Genevisible; Q9UBN6; HS GO; GO:0009986; C:cell surface; IBA:GO_Central GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0005886; C:plasma membrane; IBA:GO_Central GO; GO:0045569; F:TRAIL binding; IEA:InterPro GO; GO:0004888; F:transmembrane signaling receptor activity; TAS:ProtInc GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW GO; GO:0007166; P:cell surface receptor signaling pathway; TAS:Reactome GO; GO:0050900; P:leukocyte migration; TAS:Reactome GO; GO:0043066; P:negative regulation of apoptotic process; TAS:ProtInc GO; GO:0042981; P:regulation of apoptotic process; TAS:Reactome GO; GO:0007165; P:signal transduction; TAS:ProtInc CDD; cd10580; TNFRSF10; 1 InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg InterPro; IPR020465; TNFR_10 InterPro; IPR034024; TNFRSF10_N Pfam; PF00020; TNFR_c6; 2 PRINTS; PR01956; TNFACTORR10 SMART; SM00208; TNFR; 2 PROSITE; PS00652; TNFR_NGFR_1; 2 PROSITE; PS50050; TNFR_NGFR_2; 2 1: Evidence at protein level; Apoptosis; Direct protein sequencing; Disulfide bond; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix SIGNAL 1..55 /evidence="ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:9382840" CHAIN 56..386 /note="Tumor necrosis factor receptor superfamily member 10D" /id="PRO_0000034584" TOPO_DOM 56..211 /note="Extracellular" /evidence="ECO:0000255" TRANSMEM 212..232 /note="Helical" /evidence="ECO:0000255" TOPO_DOM 233..386 /note="Cytoplasmic" /evidence="ECO:0000255" REPEAT 58..97 /note="TNFR-Cys 1" REPEAT 98..139 /note="TNFR-Cys 2" REPEAT 140..180 /note="TNFR-Cys 3" DOMAIN 340..366 /note="Death; truncated" COMPBIAS 225..228 /note="Poly-Val" COMPBIAS 246..250 /note="Poly-Gly" CARBOHYD 127 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" CARBOHYD 182 /note="N-linked (GlcNAc...) asparagine" /evidence="ECO:0000255" DISULFID 83..96 /evidence="ECO:0000255|PROSITE-ProRule:PRU00206" DISULFID 99..115 /evidence="ECO:0000255|PROSITE-ProRule:PRU00206" DISULFID 118..131 /evidence="ECO:0000255|PROSITE-ProRule:PRU00206" DISULFID 121..139 /evidence="ECO:0000255|PROSITE-ProRule:PRU00206" DISULFID 141..155 /evidence="ECO:0000255|PROSITE-ProRule:PRU00206" DISULFID 158..172 /evidence="ECO:0000255|PROSITE-ProRule:PRU00206" DISULFID 162..180 /evidence="ECO:0000255|PROSITE-ProRule:PRU00206" VARIANT 35 /note="P -> S (in TRAIL-R4-B; dbSNP:rs11135703)" /evidence="ECO:0000269|PubMed:9430226" /id="VAR_011417" VARIANT 276 /note="R -> H (in dbSNP:rs55636833)" /id="VAR_061854" VARIANT 310 /note="S -> L (in TRAIL-R4-B; dbSNP:rs1133782)" /evidence="ECO:0000269|PubMed:9430226" /id="VAR_011418" VARIANT 345 /note="T -> P (in dbSNP:rs34622674)" /id="VAR_057288" SEQUENCE 386 AA; 41823 MW; 77A93577CAAF2632 CRC64; MGLWGQSVPT ASSARAGRYP GARTASGTRP WLLDPKILKF VVFIVAVLLP VRVDSATIPR QDEVPQQTVA PQQQRRSLKE EECPAGSHRS EYTGACNPCT EGVDYTIASN NLPSCLLCTV CKSGQTNKSS CTTTRDTVCQ CEKGSFQDKN SPEMCRTCRT GCPRGMVKVS NCTPRSDIKC KNESAASSTG KTPAAEETVT TILGMLASPY HYLIIIVVLV IILAVVVVGF SCRKKFISYL KGICSGGGGG PERVHRVLFR RRSCPSRVPG AEDNARNETL SNRYLQPTQV SEQEIQGQEL AELTGVTVES PEEPQRLLEQ AEAEGCQRRR LLVPVNDADS ADISTLLDAS ATLEEGHAKE TIQDQLVGSE KLFYEEDEAG SATSCL
Research Areas
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TNFRSF is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis.


Davila, S., et al. Genes Immun. (2010) In press : Pei, G.T., et al. Biochem. Biophys. Res. Commun. 391(2):1274-1279(2010) Lucas, H., et al. J. Dent. Res. 89(1):29-33(2010) Hosgood, H.D. III, et al. Occup Environ Med 66(12):848-853(2009) Chen, B., et al. Spine 34 (19), E677-E681 (2009) :

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$ 277.78
Cat# BP9526c
Availability: 2 weeks
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