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TMEM108 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6UXF1
Additional Information
Gene ID 66000
Other Names Transmembrane protein 108, TMEM108, KIAA1690
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TMEM108 (HGNC:28451)
Synonyms KIAA1690, RTLN
Function Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes.
Cellular Location Membrane {ECO:0000250|UniProtKB:Q8BHE4}; Multi- pass membrane protein. Cell junction, synapse, postsynaptic density {ECO:0000250|UniProtKB:Q8BHE4}. Endosome membrane {ECO:0000250|UniProtKB:Q8BHE4}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BHE4}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BHE4}. Early endosome {ECO:0000250|UniProtKB:Q8BHE4}
Research Areas
Citations (0)

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References

Uhl, G.R., et al. Arch. Gen. Psychiatry 65(6):683-693(2008)Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)

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$ 277.78
Cat# BP9598b
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