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APR3 Antibody (Center) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q6UW56 |
|---|
| Gene ID | 51374 |
|---|---|
| Other Names | All-trans retinoic acid-induced differentiation factor, Apoptosis-related protein 3, APR-3, p18, ATRAID, APR3, C2orf28 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ATRAID (HGNC:24090) |
|---|---|
| Synonyms | APR3, C2orf28 |
| Function | Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphophonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol (PubMed:29745899). |
| Cellular Location | Nucleus envelope. Cell membrane; Single-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Note=Colocalizes with NELL1 on the nuclear envelope and the perinuclear region (PubMed:21723284) |
| Tissue Location | Weakly expressed in hematopoietic cell lines. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
APR3 may play a critical role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway.
References
Yu, F., et al. Biochem. Biophys. Res. Commun. 358(4):1041-1046(2007)Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)Zhu, F., et al. BioTechniques 29(2):310-313(2000)
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