|Other Names||Oxytocin-neurophysin 1, OT-NPI, Oxytocin, Ocytocin, Neurophysin 1, OXT, OT|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Neurophysin 1 specifically binds oxytocin.|
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Provided below are standard protocols that you may find useful for product applications.
There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.
Rao, V.V., et al. Cytogenet. Cell Genet. 61(4):271-273(1992)Ivell, R., et al. Endocrinology 127(6):2990-2996(1990)Wood, S.P., et al. Science 232(4750):633-636(1986)Sausville, E., et al. J. Biol. Chem. 260(18):10236-10241(1985)
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