|Other Names||Luc7-like protein 3, Cisplatin resistance-associated-overexpressed protein, Luc7A, Okadaic acid-inducible phosphoprotein OA48-18, cAMP regulatory element-associated protein 1, CRE-associated protein 1, CREAP-1, LUC7L3, CREAP1, CROP, O48|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CREAP1, CROP, O48|
|Function||Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing.|
|Cellular Location||Nucleus speckle. Note=The subnuclear localization is affected by cisplatin|
|Tissue Location||Widely expressed. Highest levels in heart, brain, pancreas, thymus, ovary, small intestine and peripheral blood leukocytes, as well as cerebellum, putamen and pituitary gland. Lowest levels in lung, liver and kidney. Also expressed in fetal tissues, including brain, heart, kidney, thymus and lung|
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Provided below are standard protocols that you may find useful for product applications.
CROP is a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains.
Webby, C.J., et al. Science 325(5936):90-93(2009)Zhou, A., et al. Mol. Cell. Biol. 28(19):5924-5936(2008)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
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