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RAB11FIP4 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q86YS3 |
|---|
| Gene ID | 84440 |
|---|---|
| Other Names | Rab11 family-interacting protein 4, FIP4-Rab11, Rab11-FIP4, Arfophilin-2, RAB11FIP4, ARFO2, KIAA1821 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RAB11FIP4 |
|---|---|
| Synonyms | ARFO2, KIAA1821 |
| Function | Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. |
| Cellular Location | Endosome. Cytoplasm, cytoskeleton, spindle Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Recycling endosome membrane; Peripheral membrane protein. Cleavage furrow. Midbody. Cytoplasmic vesicle. Note=Recruited to the cleavage furrow and the midbody during cytokinesis |
| Tissue Location | Present at high level in testis (at protein level). Weakly expressed in other tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP4 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001 [PubMed 11495908]).
References
Douglas, J., et al. Nat. Genet. 39(8):963-965(2007)Shiba, T., et al. Proc. Natl. Acad. Sci. U.S.A. 103(42):15416-15421(2006)Lim, J., et al. Cell 125(4):801-814(2006)Fielding, A.B., et al. EMBO J. 24(19):3389-3399(2005)Wilson, G.M., et al. Mol. Biol. Cell 16(2):849-860(2005)
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