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PRUNE Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q86TP1
Additional Information
Gene ID 58497
Other Names Protein prune homolog, hPrune, Drosophila-related expressed sequence 17, DRES-17, DRES17, HTcD37, PRUNE
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name PRUNE1 (HGNC:13420)
Synonyms PRUNE
Function Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1. Plays a role in the regulation of neurogenesis (PubMed:28334956). Involved in the regulation of microtubule polymerization (PubMed:28334956).
Cellular Location Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed
Tissue Location Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas.
Research Areas
Citations (0)

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Background

Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. It plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1.

References

Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)Middelhaufe, S., et al. Biochem. J. 407(2):199-205(2007)Kobayashi, T., et al. Mol. Cell. Biol. 26(3):898-911(2006)Zollo, M., et al. Clin. Cancer Res. 11(1):199-205(2005)Forus, A., et al. Oncogene 20(47):6881-6890(2001)Reymond, A., et al. Oncogene 18(51):7244-7252(1999)

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$ 277.78
Cat# BP9748b
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