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Cathepsin D (active, human) recombinant protein
Cathepsin D (active, human)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P07339 |
|---|---|
| Calculated MW | 44552 Da |
| Gene ID | 1509 |
|---|---|
| Gene Symbol | CTSB |
| Other Names | Cathepsin D |
| Gene Source | Human |
| Source | Human liver |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | HPLC; |
| Recombinant | No |
| Target/Specificity | Cathepsin D |
| Application Notes | Reconstitute the vial in H₂O to a concentration of 0.1-1 µg/ µl. Aliquot and refreeze at -80°C immediately for future use. |
| Format | Lyophilized |
| Storage | -80°C; Lyophilized from a solution containing 2 mM sodium phosphate, pH 6.5 |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cathepsin D is an estrogen-regulated protein associated with tissue breakdown. Levels of cathepsin D have been positively correlated with recurring breast cancers of both node negative and node positive types. Additionally cathepsin D has been associated with amyloid formation in Alzheimer’s plaques. As cathepsin D activity is increased by cigarette smoke, the enzyme may contribute to lung tissue damage in smokers.
References
Faust P.L.,et al.Proc. Natl. Acad. Sci. U.S.A. 82:4910-4914(1985).
Westley B.R.,et al.Nucleic Acids Res. 15:3773-3786(1987).
Redecker B.,et al.DNA Cell Biol. 10:423-431(1991).
Ebert L.,et al.Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
Kalnine N.,et al.Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
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