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Eotaxin/CCL11, human recombinant protein
human Eotaxin
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P51671 |
|---|---|
| Calculated MW | 8.3 kDa |
| Gene ID | 6356 |
|---|---|
| Gene Symbol | CCL-11 |
| Other Names | Eotaxin, C-C motif chemokine 11, Eosinophil chemotactic protein, Small-inducible cytokine A11 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥97% |
| Assay2&Purity2 | HPLC; ≥97% |
| Recombinant | Yes |
| Results | 10 ng/ ml |
| Target/Specificity | Eotaxin |
| Application Notes | The lyophilized Eotaxin can be reconstituted in water to a concentration of 0.1-1 µg/ µl. It is recommended that further dilutions be made into buffer containing carrier protein or medium containing serum. |
| Format | Lyophilized protein |
| Storage | -20°C; Lyophilized from 20 mM phosphate buffer (pH 7.4) and 150 mM NaCl. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Eotaxin is a recently discovered chemokine characterized by its high chemotactic selectivity for eosinophils. The position of the four cystein residues in Eotaxin places it in the C-C family of chemokines, along with chemokines such as RANTES, MCP-3, and MIP-1 alpha. The human Eotaxin is an 8.3 kDa protein containing 74 amino acid residues. The sequence of the first five N-terminal amino acids is Gly-Pro-Ala-Ser-Val.
References
Garcia-Zepeda E.A.,et al.Nat. Med. 2:449-456(1996).
Ponath P.D.,et al.J. Clin. Invest. 97:604-612(1996).
Kitaura M.,et al.J. Biol. Chem. 271:7725-7730(1996).
Bartels J.,et al.Biochem. Biophys. Res. Commun. 225:1045-1051(1996).
Garcia-Zepeda E.A.,et al.Genomics 41:471-476(1997).
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