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flt-3-Ligand, murine recombinant protein
Fms-related tyrosine kinase 3 ligand
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P49772 |
|---|---|
| Calculated MW | 16.4 kDa |
| Gene ID | 14256 |
|---|---|
| Gene Symbol | Flt3-L |
| Other Names | Fms-related tyrosine kinase 3 ligand, Short name=Flt3 ligand, Short name=Flt3L, SL cytokine |
| Gene Source | Mouse |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; ≥98% |
| Recombinant | Yes |
| Results | 5-8 ng/ml |
| Target/Specificity | Flt-3 Ligand |
| Application Notes | Reconstitute in H₂O to a concentration of 0.1 – 1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. |
| Format | Lyophilized protein |
| Storage | -20°C; Sterile filtered and lyophilized with no additives. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Flt3-Ligand belongs to a small group of growth factors that regulate proliferation of early hematopoietic cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant form is the transmembrane which is biologically active on the cell surface. The proteolytically cleaved transmembrane isoform generates a soluble form, which is also biologically active. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand alone cannot stimulate proliferation, but synergizes well with other CSFs and interleukins to induce growth and differentiation. Recombinant murine flt3-Ligand is a 16.4 kDa protein containing 144 amino acid residues.
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