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Eosinophil Peroxidase, Human Eosinophils recombinant protein
EPO
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P11678 |
|---|---|
| Calculated MW | 70.5 kDa |
| Gene ID | 8288 |
|---|---|
| Gene Symbol | EPX |
| Other Names | EPO, EPER, EPP |
| Gene Source | Human |
| Source | Human eosinophils |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | HPLC; |
| Recombinant | No |
| Target/Specificity | Eosinophil Peroxidase |
| Application Notes | Reconstitute in deionized H₂O. Aliquot and store at –20°C. Avoid freeze-thaw cycles. |
| Format | Lyophilized protein |
| Storage | -20°C; Lyophilized from 20 mM NaH2PO4, pH 7.5, and 150 mM NaCI |
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Provided below are standard protocols that you may find useful for product applications.
Background
Native, human eosinophil peroxidase is a secreted hemoprotein that catalyzes oxidations of various substrates by hydrogen peroxide. Together with other leukocyte-derived enzymes, such as Myeloperoxidase, EPO plays an important role in the pathogenesis of asthma by mediating oxidative events that lead to the production of ROS (reactive oxygen species) and RNS (reactive nitrogen species).
References
Sakamaki K.,et al.J. Biol. Chem. 264:16828-16836(1989).
Ten R.M.,et al.J. Exp. Med. 169:1757-1769(1989).
Oxvig C.,et al.J. Biol. Chem. 274:16953-16958(1999).
Borelli V.,et al.Infect. Immun. 71:605-613(2003).
Ulrich M.,et al.J. Biol. Chem. 283:28629-28640(2008).
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