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IL-4, rat recombinant protein
BCGF,BCDF, B cell stimulating factor, BSF-1,Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetra
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P20096 |
|---|---|
| Calculated MW | 14.1 kDa |
| Gene ID | 287287 |
|---|---|
| Gene Symbol | IL4 |
| Other Names | BCGF, BCDF, B cell stimulating factor, BSF-1, Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetrakin, Pitrakinra, |
| Gene Source | Rat |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; ≥98% |
| Recombinant | Yes |
| Results | < 1.5 ng/ml |
| Sequence | Amino acids residue 25-147 (122 amino acids) of rat IL-4 |
| Target/Specificity | IL-4 |
| Application Notes | Reconstitute in H₂O to a concentration of 0.1-1 mg/ml. The solution can be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. |
| Format | Lyophilized protein |
| Storage | -20°C; Lyophilized with no additives. |
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Provided below are standard protocols that you may find useful for product applications.
Background
IL4 is a pleiotropic cytokine and a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B cells and T cells. It is produced by activated T cells and is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
References
McKnight A.J.,et al.Eur. J. Immunol. 21:1187-1194(1991).
Richter G.,et al.Cytokine 2:221-228(1990).
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