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IL-5, murine recombinant protein
Interleukin-5, IL-5, B-cell growth factor II, BCGF-II, Cytotoxic T-lymphocyte inducer, Eosinophil di
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P04401 |
|---|---|
| Calculated MW | 26.2 kDa |
| Gene ID | 16191 |
|---|---|
| Gene Symbol | IL5 |
| Other Names | Interleukin-5, IL-5, B-cell growth factor II, BCGF-II, Cytotoxic T-lymphocyte inducer, Eosinophil differentiation factor, T-cell replacing factor, TRF, Interleukin 5, IL-5, IL 5, IL-5, |
| Gene Source | Mouse |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥97% |
| Assay2&Purity2 | HPLC; ≥97% |
| Recombinant | Yes |
| Results | 1.7ng/ml. |
| Target/Specificity | IL-5 |
| Application Notes | It is recommended to reconstitute the lyophilized product with sterile H₂O at a concentration of 0.1 mg/ml, which can be further diluted into other aqueous solutions. |
| Format | Lyophilized protein |
| Storage | -20°C; Lyophilized from 20 mM Sodium phosphate buffer, pH 7.5 |
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Provided below are standard protocols that you may find useful for product applications.
Background
Mouse Interleukin-5 (mIL-5) is a glycoprotein also known as EDF and TRF. It is involved in B-cell growth and eosinophil activation. IL-5 has been shown to be expressed in Th2, mast cells and eosinophils and is regulated by GATA-3, in addition to other transcription factors. IL-5 signals its biological effect through interaction with the IL-5 receptor (IL-5R). Recombinant mIL-5 is produced in E.Coli, comprised of two 113 amino acid chains forming a disulfide-linked homodimer with a molecular weight of 26.2 kDa.
References
Campbell H.D.,et al.Eur. J. Biochem. 174:345-352(1988).
Kinashi T.,et al.Nature 324:70-73(1986).
Mizuta T.R.,et al.Growth Factors 1:51-57(1988).
Takahashi T.,et al.Mol. Immunol. 27:911-920(1990).
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