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IL-6, murine recombinant protein
IFN-b2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2, IL-6, Interleukin HP-1, B-cel
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P08505 |
|---|---|
| Calculated MW | 21.7 kDa |
| Gene ID | 16193 |
|---|---|
| Gene Symbol | IL6 |
| Other Names | IFN-b2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2, IL-6, Interleukin HP-1, B-cell hybridoma growth factor, B-cell stimulatory factor 2, CTL differentiation factor, Interferon beta-2. |
| Gene Source | Mouse |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; ≥98% |
| Recombinant | Yes |
| Results | <0.02 ng/ml |
| Target/Specificity | IL-6 |
| Application Notes | Reconstitute in H₂O to a concentration of 0.1-1.0 µg/ µl. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. |
| Format | Lyophilized protein |
| Storage | -20°C; Lyophilized with no additives. |
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Provided below are standard protocols that you may find useful for product applications.
Background
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 187 amino acid residues.
References
van Snick J.,et al.Eur. J. Immunol. 18:193-197(1988).
Tanabe O.,et al.J. Immunol. 141:3875-3881(1988).
Chiu C.P.,et al.Proc. Natl. Acad. Sci. U.S.A. 85:7099-7103(1988).
Grenett H.E.,et al.Nucleic Acids Res. 18:6455-6455(1990).
Carninci P.,et al.Science 309:1559-1563(2005).
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