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Survivin, human recombinant protein


Product info
Primary Accession O15392
Calculated MW 18.6 kDa
Additional Info
Gene ID 332
Gene Symbol BIRC5
Other Names Survivin, BIRC5; API4; EPR-1, Apoptosis inhibitor 4, Apoptosis inhibitor survivin
Gene Source Human
Source E. coli
Assay&Purity SDS-PAGE; ≥90%
Assay2&Purity2 HPLC;
Recombinant Yes
Target/Specificity Survivin
Application Notes Reconstitute to a concentration of 0.1-1.0 mg/ml in PBS.
Format Lyophilized protein
Storage -20°C; Sterile filtered and lyophilized with no additives
Citations (0)

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Survivin, a member of the inhibitor of apoptosis (IAP) family, is also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5 and in humans is encoded by the BIRC5 gene. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis. Disruption of survivin induction pathways leads to an increase in apoptosis and decrease in tumour growth. Survivin is highly expressed in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells, making survivin an ideal target for studying cancer therapy.


Ambrosini G.,et al.Nat. Med. 3:917-921(1997).
Mahotka C.,et al.Cancer Res. 59:6097-6102(1999).
Uren A.G.,et al.Curr. Biol. 10:1319-1328(2000).
Badran A.,et al.Biochem. Biophys. Res. Commun. 314:902-907(2004).
Zheng W.,et al.DNA Seq. 16:321-328(2005).

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$ 115.00
$ 2,950.00
$ 325.00
Cat# PBV10141r-10
Availability: 5-7days
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