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IL-1 RA, human recombinant protein
IRAP, IL1F3, IL1RA, IL-1ra3, ICIL-1RA, IL1RN, IL1 inhibitor, IL-1ra, MGC10430
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P18510 |
|---|---|
| Calculated MW | 17.0 kDa |
| Gene ID | 3557 |
|---|---|
| Gene Symbol | IL-1RA |
| Other Names | IRAP, IL1F3, IL1RA, IL-1ra3, ICIL-1RA, IL1RN, IL1 inhibitor, IL-1ra, MGC10430 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; ≥98% |
| Recombinant | Yes |
| Results | 0.5 ng/ml. |
| Sequence | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Arg-Pro-Ser-Gly. |
| Target/Specificity | IL-1 RA |
| Application Notes | Centrifuge the vial prior to opening. Reconstitute in sterile H₂O to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers. |
| Format | Lyophilized protein |
| Storage | -20°C; Lyophilized without additves |
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Provided below are standard protocols that you may find useful for product applications.
Background
Interleukin-1 RA is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1-alpha (IL1A) and interleukin 1-beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. IL1RA Human Recombinant produced in E.Coli is a non-glycosylated, N-terminal methionyl form of the human naturally-occurring polypeptide chain containing 153 amino acids and having a molecular mass of 17000 Dalton. The IL1RA is purified by proprietary chromatographic techniques.
References
Carter D.B.,et al.Nature 344:633-638(1990).
Eisenberg S.P.,et al.Nature 343:341-346(1990).
Eisenberg S.P.,et al.Proc. Natl. Acad. Sci. U.S.A. 88:5232-5236(1991).
Lennard A.,et al.Cytokine 4:83-89(1992).
Jenkins J.K.,et al.J. Immunol. 158:748-755(1997).
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