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CXCL10/IP-10/CRG-2, human recombinant protein
10 kDa interferon gamma-induced protein, Gamma-IP10, IP-10, Small-inducible cytokine B10
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P02778 |
|---|---|
| Calculated MW | 8.8 kDa |
| Gene ID | 3627 |
|---|---|
| Gene Symbol | CXCL10 |
| Other Names | C-X-C motif chemokine 10 (10 kDa interferon gamma-induced protein) (Gamma-IP10) (IP-10) (Small-inducible cytokine B10) Cleaved into: CXCL10(1-73) |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | HPLC; ≥95% |
| Recombinant | Yes |
| Results | 0.02-0.06 µg/ml |
| Sequence | Recombinant human CXCL10/IP-10/CRG-2 is produced by E.coli transformed with a plasmid contains sequence (Val22-Pro98) of human CXCL10/IP-10/CRG-2 (Uniprot Entry: P02778) fused with a polyhistidine tag at the C-terminus. The sequence of the first five N-terminal amino acids was determined and was found to be Val-Pro-Leu-Ser-Arg. |
| Target/Specificity | CXCL-10 |
| Application Notes | Dissolve in 1x PBS (It is not recommended to reconstitute to a final concentration less than 100 µg/ml). This can further be diluted to other aqueous buffers. |
| Format | Lyophilized protein |
| Storage | -20°C; Lyophilized from a 0.2 µm filtered solution of 20 mM PB and 150 mM NaCl, pH 7.0. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Human Chemokine (C-X-C motif) ligand 10(CXCL10),also known as Interferon gamma-inducible protein-10 (IP-10), is a non-ELR chemokine secreted by various cell types including monocytes, endothelial cells and fibroblasts in response to IFN-γ. CXCL10 functions via chemokine receptor CXCR3. CXCL10 has been attributed to several roles, such as chemo-attraction for activated T-lymphocytes, inhibition of angiogenesis and antitumor activity.
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