CXCL14/BRAK, human recombinant protein
Chemokine BRAK, MIP-2G, Small-inducible cytokine B14
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O95715 |
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Calculated MW | ~9.4 kDa |
Gene ID | 9547 |
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Gene Symbol | CXCL14 |
Other Names | C-X-C motif chemokine 14 (Chemokine BRAK) (MIP-2G) (Small-inducible cytokine B14) |
Gene Source | Human |
Source | E. coli |
Assay&Purity | SDS-PAGE; ≥95% |
Assay2&Purity2 | HPLC; ≥95% |
Recombinant | Yes |
Results | 1.0-10.0 ng/ml |
Sequence | Recombinant Human CXCL14 produced in E. coli is a single, non-glycosylated, polypeptide chain containing 77 amino acids and having a molecular mass of 9.4 kDa. The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Lys-Cys-Lys-Cys. |
Target/Specificity | CXCL-14 |
Application Notes | Reconstitute the lyophilized recombinant human CXCL14 in sterile 18MΩ-cm H2O not less than 100 µg/ml. This can further be diluted to other aqueous buffers. |
Format | Lyophilized protein |
Storage | -20°C; Lyophilized from a 0.2 µm filtered solution of 20 mM Tris HCl and 1 M NaCl, pH 8.5. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Human Chemokine (C-X-C motif) ligand 14(hCXCL14),also known as breast and kidney-expressed chemokine (BRAK), MIP-2 gamma, kidney-expressed chemokine (KEC), and B cell and monocyte-activating chemokine (BMAC), is a CXC chemokine constitutively expressed in certain normal tissues but is reduced or absent from many established tumor cell lines and human cancers. CXCL14 is known to be a chemo-attractant for monocyte and dendritic cells. CXCL14 inhibits angiogenesis and exhibits antimicrobial activities. Mature human and mouse CXCL14 differ by only 2 residues.
References
Frederick M.J.,et al.Am. J. Pathol. 156:1937-1950(2000).
Cao X.,et al.J. Immunol. 165:2588-2595(2000).
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Otsuki T.,et al.DNA Res. 12:117-126(2005).
Kalnine N.,et al.Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
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