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TPO, human recombinant protein
TPO, human recombinant
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P07202 |
|---|---|
| Calculated MW | 102963 Da |
| Gene ID | 7173 |
|---|---|
| Gene Symbol | TPO |
| Other Names | Megakaryocyte colony-stimulating factor, Myeloproliferative leukemia virus oncogene ligand, C-mpl ligand, ML, Megakaryocyte growth and development factor, MGDF, TPO, MKCSF, MPLLG, MGC163194, THPO. |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; ≥98% |
| Recombinant | Yes |
| Results | <1 ng/ml |
| Target/Specificity | TPO |
| Application Notes | Reconstitution in purified H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. For long term storage it is recommended to add a carrier protein (0.1% HAS or BSA). |
| Format | Lyophilized protein |
| Storage | -20°C; Lyophilized with no additives |
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Provided below are standard protocols that you may find useful for product applications.
Background
TPO (Thrombopoietin, also known as Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide, which contains the erythropoietin-like domain of the full length TPO protein.
References
Kimura S.,et al.Proc. Natl. Acad. Sci. U.S.A. 84:5555-5559(1987).
Libert F.,et al.Nucleic Acids Res. 15:6735-6735(1987).
Kimura S.,et al.Biochemistry 28:4481-4489(1989).
Barnett P.S.,et al.Nucleic Acids Res. 18:670-670(1990).
Rapoport B.,et al.Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
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