PF 4, human platelets recombinant protein
CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298.
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P02776 |
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Calculated MW | 7.8 kDa |
Gene ID | 5196 |
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Gene Symbol | PLF4 |
Other Names | CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298. |
Gene Source | Human |
Source | Human platelets |
Assay&Purity | SDS-PAGE; ≥95% |
Assay2&Purity2 | HPLC; ≥95% |
Recombinant | No |
Sequence | The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu. |
Target/Specificity | PF 4 |
Application Notes | Reconstitute in sterile ddH₂O to a concentration ≥ 100 µg/ml. This solution can then be diluted into other aqueous buffers. |
Format | Lyophilized protein |
Storage | -20°C; Lyophilized from PBS buffer, pH 7.4. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy. Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues.
References
Poncz M.,et al.Blood 69:219-223(1987).
Eisman R.,et al.Blood 76:336-344(1990).
Zhang C.,et al.Blood 98:610-617(2001).
Ebert L.,et al.Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
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