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BD-1, human recombinant protein
β-defensin 1, BD-1, Defensin β 1, hBD-1, HBD1, HBP1, DEFB1, HBD-1, HBP-1, DEFB101, DEFB-1, MGC51822
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P60022 |
|---|---|
| Calculated MW | 5.0 kDa |
| Gene ID | 1672 |
|---|---|
| Gene Symbol | DEFB1 |
| Other Names | β-defensin 1, BD-1, Defensin β 1, hBD-1, HBD1, HBP1, DEFB1, HBD-1, HBP-1, DEFB101, DEFB-1, MGC51822 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; |
| Recombinant | Yes |
| Results | 0.1-1 µg/ml |
| Target/Specificity | BD-1 |
| Application Notes | Reconstitute in dH₂O to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use. |
| Format | Lyophilized protein |
| Storage | -20°C; Lyophilized from a concentrated (1 mg/ml) solution containing 20 mM PBS pH-7.4 and 130 mM sodium chloride |
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Provided below are standard protocols that you may find useful for product applications.
Background
The Defensin family are highly similar in their protein sequence and are microbicidal & cytotoxic peptides made by neutrophils. β Defensin-1 (BD-1) is an antimicrobial peptide having the resistance of epithelial surfaces to microbial colonization. BD-1 has close proximity to Defensin α-1 and has been implicated in the pathogenesis of cystic fibrosis. Skin of patients having atopic dermatitis patients and mycosis fungoides (non-lesional and lesional) show lower human BD-1 mRNA expression and higher human BD-2 and human BD-3 mRNA expression. β Defensin is highly expressed by epithelial cells. BD-1 may play a role in the pathogenesis of severe sepsis. Variation in human BD-1 contributes to asthma diagnosis, with apparent gender-specific effects. Human BD-3 is a dimer, while Human BD-1 and Human BD-2 are monomeric. Recombinant human β Defensin-1 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 47 amino acids and having a molecular mass of 5 kDa.
References
Liu L.,et al.Genomics 43:316-320(1997).
Zhao C.,et al.Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
McCray P.B. Jr.,et al.Am. J. Respir. Cell Mol. Biol. 16:343-349(1997).
Bensch K.W.,et al.FEBS Lett. 368:331-335(1995).
Kluever E.,et al.J. Pept. Res. 59:241-248(2002).
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