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BMP-10, human recombinant protein
bone morphogenetic protein 10, BMP10, BMP 10
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O95393 |
|---|---|
| Calculated MW | 32 kDa |
| Gene ID | 27302 |
|---|---|
| Gene Symbol | BMP10 |
| Other Names | bone morphogenetic protein 10, BMP10, BMP 10 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; ≥98% |
| Recombinant | Yes |
| Results | 0.3-3 µg/ml |
| Target/Specificity | BMP-10 |
| Application Notes | Reconstitute to a concentration of 0.1-1.0 mg/ml in H₂O containing BSA (50 µg BSA per 1 µg of protein). This solution can then be diluted into other aqueous buffers |
| Format | Lyophilized protein |
| Storage | -20°C; Sterile filtered and lyophilized with no additives |
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Provided below are standard protocols that you may find useful for product applications.
Background
BMPs (bone morphogenetic proteins) belong to the TGF-β superfamily of structurally related signaling proteins. As implied by their name, BMPs promote and regulate bone development, growth, remodeling and repair, in both prenatal development and postnatal growth of eye, heart, kidney, skin, and other tissues. BMP-10 is essential for the proper development of the heart, but is not expressed until after cardiac patterning or looping are completed. Recombinant human BMP-10 is a 32 kDa disulfide-linked homodimer containing two 142 amino acid polypeptide chains.
References
Celeste A.J.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
Hillier L.W.,et al.Nature 434:724-731(2005).
Mazerbourg S.,et al.J. Biol. Chem. 280:32122-32132(2005).
David L.,et al.Blood 109:1953-1961(2007).
Ye L.,et al.Cancer Sci. 101:2137-2144(2010).
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