Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
Human CellExp Progranulin (untagged), Rat recombinant protein
Recombinant Rat Progranulin (Untagged)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P23785 |
|---|---|
| Calculated MW | ~65.0 kDa |
| Gene ID | 10116 |
|---|---|
| Gene Symbol | GRN |
| Other Names | Proepithelin, PEPI, PC Cell-derived Growth Factor. |
| Gene Source | Rat |
| Source | HEK 293 cells |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | N/A; |
| Recombinant | Yes |
| Sequence | Signal peptide and rat progranulin (aa 1-602) is untagged. Reflects the native sequence with no additional amino acids. |
| Application Notes | Reconstitute in distilled water |
| Format | Lyophilized protein |
| Storage | -20°C; Lyophilized from 0.2 µm-filtered solution in PBS, pH 7.2. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
References
Bhandari V.,et al.Endocrinology 133:2682-2689(1993).
Plowman G.D.,et al.J. Biol. Chem. 267:13073-13078(1992).
Shoyab M.,et al.Proc. Natl. Acad. Sci. U.S.A. 87:7912-7916(1990).
Bateman A.,et al.Biochem. Biophys. Res. Commun. 173:1161-1168(1990).
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Shipping Information
