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Human CellExp Progranulin, Human recombinant protein
Acrogranin, Paragranulin, Granulin-1
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P28799 |
|---|---|
| Concentration | 0.5 |
| Calculated MW | 88.0 kDa |
| Gene ID | 2896 |
|---|---|
| Gene Symbol | GRN |
| Other Names | Acrogranin, Paragranulin, Granulin-1 |
| Gene Source | Human |
| Source | HEK 293 cells |
| Assay&Purity | SDS-PAGE; ≥90% |
| Assay2&Purity2 | HPLC; ≥90% |
| Recombinant | Yes |
| Format | Liquid |
| Storage | -20°C; Sterile filtered clear solution in PBS |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Progranulin, also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Granulins are a variety of active, 6.0 kDa peptides and named granulin A (epithelin 1), granulin B (epithelin 2), granulin C, etc. Both the peptides and intact progranulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Progranulin Human Recombinant fused to FLAG at C-terminus produced in HEK is a single, glycosylated, polypeptide chain containing 593 amino acids and having a molecular mass of 88.0 kDa. The Progranulin is purified by standard chromatographic techniques.
References
Bhandari V.,et al.Biochem. Biophys. Res. Commun. 188:57-63(1992).
Plowman G.D.,et al.J. Biol. Chem. 267:13073-13078(1992).
Bhandari V.,et al.Proc. Natl. Acad. Sci. U.S.A. 89:1715-1719(1992).
Lu R.,et al.Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
Yu W.,et al.Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
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