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GDF-3, human recombinant protein
Growth/Differentiation Factor-3
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9NR23 |
|---|---|
| Calculated MW | 13 kDa |
| Gene ID | 9573 |
|---|---|
| Gene Symbol | GDF3 |
| Other Names | Growth/Differentiation Factor-3 |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥98% |
| Assay2&Purity2 | HPLC; ≥98% |
| Recombinant | Yes |
| Application Notes | Reconstitute in H₂O to a concentration of 0.1-1.0 mg/ml. The solution can then be diluted into other aqueous buffers |
| Format | Lyophilized protein |
| Storage | -20°C; Sterile filtered and lyophilized with no additive |
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Provided below are standard protocols that you may find useful for product applications.
Background
GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type-2 diabetes. Recombinant human GDF-3 contains 114 amino acids polypeptide chains
References
Lorenz B.,et al.Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
Clark H.F.,et al.Genome Res. 13:2265-2270(2003).
Ye M.,et al.Hum. Mol. Genet. 19:287-298(2010).
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