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Endostatin, human recombinant protein
Collagen alpha-1(XVIII) chain
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P39060 |
|---|---|
| Calculated MW | 20.5 kDa |
| Gene ID | 80781 |
|---|---|
| Gene Symbol | COL18A1 |
| Other Names | Collagen alpha-1(XVIII) chain, Endostatin-XV, Related to endostatin, Restin |
| Gene Source | Human |
| Source | E. coli |
| Assay&Purity | SDS-PAGE; ≥95% |
| Assay2&Purity2 | HPLC; |
| Recombinant | Yes |
| Application Notes | Reconstitute with sterile dH₂O to a concentration ≥ 1.0 mg/ml, aliquot and store at below –20°C. Avoid freeze-thaw cycles. |
| Format | Lyophilized protein |
| Storage | -20°C; Sterile filtered and lyophilized from 50 mM Tris, pH 8.0 |
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Provided below are standard protocols that you may find useful for product applications.
Background
Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin family Endostatin specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes. Recombinant human Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin treatment results in apoptosis of HUVE and HMVE cells.
References
Saarela J.,et al.Matrix Biol. 16:319-328(1998).
Elamaa H.,et al.Matrix Biol. 22:427-442(2003).
Hattori M.,et al.Nature 405:311-319(2000).
Oh S.P.,et al.Genomics 19:494-499(1994).
Feng Y.,et al.Sheng Wu Gong Cheng Xue Bao 17:278-282(2001).
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