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PACAP (Human, 6-38)
Synthetic Peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O70176 |
|---|---|
| Other Accession | P41534, P13589, Q29W19, P18509, P16613 |
| Sequence | NH2-FTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK-CONH2 |
| Gene ID | 11516 |
|---|---|
| Other Names | Pituitary adenylate cyclase-activating polypeptide, PACAP, PACAP-related peptide, PRP-48, Pituitary adenylate cyclase-activating polypeptide 27, PACAP-27, PACAP27, Pituitary adenylate cyclase-activating polypeptide 38, PACAP-38, PACAP38, Adcyap1, Pacap |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | Adcyap1 {ECO:0000312|MGI:MGI:105094} |
|---|---|
| Synonyms | Pacap |
| Function | PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1) (By similarity). Exerts neuroprotective and general cytoprotective effects due to anti- apoptotic, anti-inflammatory, and antioxidant actions (PubMed:18055122). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (PubMed:23913443). PACAP exists in two bioactive forms from proteolysis of the same precursor protein, PACAP27 and PACAP38, which differ by eleven amino acid residues in the C-terminus (By similarity). |
| Cellular Location | Secreted. |
Research Areas
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Application Protocols
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$ 277.78
Cat# SP2119a
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