C10orf58 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
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Primary Accession | Q9BRX8 |
Other Accession | Q3ZBK2, NP_115709.3 |
Reactivity | Human |
Predicted | Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 25764 Da |
Antigen Region | 181-209 aa |
Gene ID | 84293 |
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Other Names | Redox-regulatory protein FAM213A, Peroxiredoxin-like 2 activated in M-CSF stimulated monocytes, Protein PAMM, FAM213A, C10orf58, PAMM |
Target/Specificity | This C10orf58 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 181-209 amino acids from the C-terminal region of human C10orf58. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | C10orf58 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PRXL2A (HGNC:28651) |
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Function | Involved in redox regulation of the cell (PubMed:26438880, PubMed:19951071). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880). |
Cellular Location | Cytoplasm. Secreted. Note=Secreted from mature adipocytes but not from preadipocytes. |
Tissue Location | Expressed in CSF1 and TNFSF11-stimulated CD14(+) peripheral blood mononuclear cells (PBMCs) |
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Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of the protein remains unknown.
References
Castellano, S., et al. EMBO Rep. 5(1):71-77(2004)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
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