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METTL23 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS: 1
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q86XA0 |
| Other Accession | Q5RJL2, A2AA28, NP_001073979.2 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 21469 Da |
| Antigen Region | 138-166 aa |
| Gene ID | 124512 |
|---|---|
| Other Names | Methyltransferase-like protein 23, 211-, METTL23, C17orf95 |
| Target/Specificity | This C17orf95 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 138-166 amino acids from the C-terminal region of human C17orf95. |
| Dilution | WB~~1:1000 E~~Use at an assay dependent concentration. |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | METTL23 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | METTL23 {ECO:0000303|PubMed:24501276, ECO:0000312|HGNC:HGNC:26988} |
|---|---|
| Function | Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling (By similarity). Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation (By similarity). |
| Cellular Location | Nucleus. Cytoplasm Note=Localizes in male and female zygote pronucleus and cytoplasm {ECO:0000250|UniProtKB:A2AA28} |
Research Areas
Citations ( 0 )
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
The specific function of the protein remains unknown.
References
Strausberg, R.L., et al. Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903(2002)
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$ 150.00
$ 385.00
Cat# AP13464b
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