Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > C9orf7 Antibody (C-term)
C9orf7 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UGQ2 |
| Other Accession | D4A9I3, Q8BG21, NP_060056.1, NP_001129247.1 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 18470 Da |
| Antigen Region | 123-151 aa |
| Gene ID | 11094 |
|---|---|
| Other Names | Calcium channel flower homolog, Calcium channel flower domain-containing protein 1, CACFD1, C9orf7 |
| Target/Specificity | This C9orf7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 123-151 amino acids from the C-terminal region of human C9orf7. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | C9orf7 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CACFD1 |
|---|---|
| Synonyms | C9orf7 |
| Function | Transmembrane protein which mediates synaptic endocytosis and fitness-based cell culling (PubMed:31341286, PubMed:37348560). In response to different stimulus strengths, controls two major modes of synaptic vesicle (SV) retrieval in hippocampal neurons; Clathrin- mediated endocytosis (CME) in response to mild stimulation and activity-dependent bulk endocytosis (ADBE) in response to strong stimulation (By similarity). In cytotoxic T-lymphoocytes (CTLs) facilitates calcium-dependent endocytosis of cytotoxic granules at the immuno synapse (By similarity). Different isoforms work as fitness fingerprints in 'loser' and 'winner' cells and thereby mediate win/lose decisions as part of the cell competition process (PubMed:31341286). |
| Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:D4A9I3}. Golgi apparatus {ECO:0000250|UniProtKB:D4A9I3}. Vesicle {ECO:0000250|UniProtKB:Q8BG21} Note=In cytotoxic T-lymphoocytes, localizes to intracellular vesicles that move to the immuno synapse (By similarity). Enriched in synaptic vesicles at the presynpatic vesicles (By similarity). Detected in the Golgi apparatus of cultured hippocampal neurons (By similarity) {ECO:0000250|UniProtKB:D4A9I3, ECO:0000250|UniProtKB:Q8BG21} [Isoform 2]: Endoplasmic reticulum membrane; Multi-pass membrane protein |
| Tissue Location | Detected in skin cells at low levels of expression (at protein level). |
Research Areas
Citations (0)
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
Submit your citation using an Abcepta antibody to
info@abcepta.com, and receive a free "I Love Antibodies" mug.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
C9orf7 belongs to the calcium channel flower family.
References
Yao, C.K., et al. Cell 138(5):947-960(2009)
Yuan, X., et al. Am. J. Hum. Genet. 83(4):520-528(2008)
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Abcepta welcomes feedback from its customers.
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
$ 365.00
$ 140.00
Cat# AP17389b
Ordering Information
United States
AlbaniaAustraliaAustriaBelgiumBosnia & HerzegovinaBrazilBulgariaCanadaCentral AmericaChinaCroatiaCyprusCzech RepublicDenmarkEstoniaFinlandFranceGermanyGreeceHong KongHungaryIcelandIndiaIndonesiaIrelandIsraelItalyJapanLatviaLithuaniaLuxembourgMacedoniaMalaysiaMaltaNetherlandsNew ZealandNorwayPakistanPolandPortugalRomaniaSerbiaSingaporeSlovakiaSloveniaSouth AfricaSouth KoreaSpainSwedenSwitzerlandTaiwanTurkeyUnited KingdomUnited StatesVietnamWorldwideOthers
USA Headquarters
(888) 735-7227 / (858) 622-0099 or (858) 875-1900
Other Products
Shipping Information
Domestic orders (in stock items)
Shipped out the same day. Orders placed after 1 PM (PST) will ship out the next business day.
International orders
Contact your local distributors
