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C2orf47 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

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  • WB - C2orf47 Antibody (C-term) AP20447b
    C2orf47 Antibody (C-term) (Cat. #AP20447b) western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the C2orf47 antibody detected the C2orf47 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8WWC4
Other Accession Q6AY04, Q8BHE8, A3KN05
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 190-219 aa
Additional Information
Other Names Uncharacterized protein C2orf47, mitochondrial, C2orf47
Target/Specificity This C2orf47 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 190-219 amino acids from the C-terminal region of human C2orf47.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsC2orf47 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MAIP1 {ECO:0000303|PubMed:27642048, ECO:0000312|HGNC:HGNC:26198}
Function Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation (PubMed:27642048). Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) (PubMed:27642048).
Cellular Location Mitochondrion matrix EMBL; AK026208; BAB15393.1; -; mRNA EMBL; AC097717; AAY24163.1; -; Genomic_DNA EMBL; CH471063; EAW70195.1; -; Genomic_DNA EMBL; BC017959; AAH17959.1; -; mRNA EMBL; AL832964; CAH56348.1; -; mRNA CCDS; CCDS2329.1; - RefSeq; NP_078796.2; NM_024520.2 BioGRID; 122716; 65 IntAct; Q8WWC4; 85 MINT; Q8WWC4; - STRING; 9606.ENSP00000295079; - iPTMnet; Q8WWC4; - PhosphoSitePlus; Q8WWC4; - BioMuta; MAIP1; - DMDM; 74730963; - EPD; Q8WWC4; - jPOST; Q8WWC4; - MassIVE; Q8WWC4; - MaxQB; Q8WWC4; - PaxDb; Q8WWC4; - PeptideAtlas; Q8WWC4; - PRIDE; Q8WWC4; - ProteomicsDB; 74877; - TopDownProteomics; Q8WWC4; - Antibodypedia; 34082; 106 antibodies DNASU; 79568; - Ensembl; ENST00000295079; ENSP00000295079; ENSG00000162972 Ensembl; ENST00000392290; ENSP00000376111; ENSG00000162972 GeneID; 79568; - KEGG; hsa:79568; - UCSC; uc002uvm.4; human CTD; 79568; - DisGeNET; 79568; - EuPathDB; HostDB:ENSG00000162972.10; - GeneCards; MAIP1; - HGNC; HGNC:26198; MAIP1 HPA; ENSG00000162972; Low tissue specificity MIM; 617267; gene neXtProt; NX_Q8WWC4; - OpenTargets; ENSG00000162972; - PharmGKB; PA162379149; - eggNOG; ENOG502QR8E; Eukaryota GeneTree; ENSGT00390000004145; - HOGENOM; CLU_083348_0_0_1; - InParanoid; Q8WWC4; - OMA; LTAIYEF; - OrthoDB; 1056493at2759; - PhylomeDB; Q8WWC4; - TreeFam; TF323801; - PathwayCommons; Q8WWC4; - Reactome; R-HSA-8949664; Processing of SMDT1 BioGRID-ORCS; 79568; 14 hits in 870 CRISPR screens GenomeRNAi; 79568; - Pharos; Q8WWC4; Tdark PRO; PR:Q8WWC4; - Proteomes; UP000005640; Chromosome 2 RNAct; Q8WWC4; protein Bgee; ENSG00000162972; Expressed in liver and 238 other tissues ExpressionAtlas; Q8WWC4; baseline and differential Genevisible; Q8WWC4; HS GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central GO; GO:0005759; C:mitochondrial matrix; IDA:UniProtKB GO; GO:0043022; F:ribosome binding; IBA:GO_Central GO; GO:0036444; P:calcium import into the mitochondrion; IMP:UniProtKB GO; GO:0007007; P:inner mitochondrial membrane organization; IBA:GO_Central GO; GO:0051560; P:mitochondrial calcium ion homeostasis; IMP:UniProtKB GO; GO:0006851; P:mitochondrial calcium ion transmembrane transport; TAS:Reactome GO; GO:0032979; P:protein insertion into mitochondrial inner membrane from matrix; IBA:GO_Central GO; GO:0051204; P:protein insertion into mitochondrial membrane; IMP:UniProtKB 1: Evidence at protein level; Mitochondrion; Polymorphism; Reference proteome; Transit peptide TRANSIT 1..96 /note="Mitochondrion" /evidence="ECO:0000255" CHAIN 97..291 /note="m-AAA protease-interacting protein 1, mitochondrial" /id="PRO_0000301945" VARIANT 290 /note="L -> I (in dbSNP:rs2118548)" /id="VAR_034911" CONFLICT 208 /note="D -> G (in Ref. 1; BAB15393)" /evidence="ECO:0000305" SEQUENCE 291 AA; 32545 MW; 97D958B2AC9C1163 CRC64; MALAARLLPQ FLHSRSLPCG AVRLRTPAVA EVRLPSATLC YFCRCRLGLG AALFPRSARA LAASALPAQG SRWPVLSSPG LPAAFASFPA CPQRSYSTEE KPQQHQKTKM IVLGFSNPIN WVRTRIKAFL IWAYFDKEFS ITEFSEGAKQ AFAHVSKLLS QCKFDLLEEL VAKEVLHALK EKVTSLPDNH KNALAANIDE IVFTSTGDIS IYYDEKGRKF VNILMCFWYL TSANIPSETL RGASVFQVKL GNQNVETKQL LSASYEFQRE FTQGVKPDWT IARIEHSKLL E
Research Areas
Citations (0)

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The function of the C2orf47 protein is currently unknown.


Ota T., et al. Nat. Genet. 36:40-45(2004).
Hillier L.W., et al. Nature 434:724-731(2005).
Mural R.J., et al. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Bechtel S., et al. BMC Genomics 8:399-399(2007).
Burkard T.R., et al. BMC Syst. Biol. 5:17-17(2011).

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Cat# AP20447b
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