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(DANRE) sh3bp4a Antibody (N-term)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q1LVQ2 |
| Reactivity | Zebrafish |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 108453 Da |
| Antigen Region | 132-165 aa |
| Gene ID | 403082 |
|---|---|
| Other Names | SH3 domain-binding protein 4-A, sh3bp4a, sh3bp4 |
| Target/Specificity | This DANRE sh3bp4a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 132-165 amino acids from the N-terminal region of DANRE sh3bp4a. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | (DANRE) sh3bp4a Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | sh3bp4a |
|---|---|
| Synonyms | sh3bp4 |
| Function | Possible role in regulating endocytosis of the transferrin receptor at the plasma membrane. Alternatively, may function as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity). |
| Cellular Location | Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Note=Specifically associated with transferrin receptor- containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus (By similarity). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Possible role in regulating endocytosis of the transferrin receptor at the plasma membrane. Alternatively, may function as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy (By similarity).
References
Howe K.,et al.Nature 496:498-503(2013).
Abe S.,et al.Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
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