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PHB Antibody (Center)
Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, WB, IF, FC, E |
|---|---|
| Primary Accession | P35232 |
| Other Accession | P84173, Q3T165 |
| Reactivity | Human |
| Predicted | Bovine, Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 29804 Da |
| Antigen Region | 89-117 aa |
| Gene ID | 5245 |
|---|---|
| Other Names | Prohibitin, PHB |
| Target/Specificity | This PHB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-117 amino acids from the Central region of human PHB. |
| Dilution | IF~~1:10~50 WB~~1:1000 IHC-P~~1:10~50 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PHB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PHB1 {ECO:0000303|PubMed:28017329, ECO:0000312|HGNC:HGNC:8912} |
|---|---|
| Function | Protein with pleiotropic attributes mediated in a cell- compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:28017329, PubMed:31522117). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (By similarity). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity). |
| Cellular Location | Mitochondrion inner membrane. Nucleus. Cytoplasm. Cell membrane |
| Tissue Location | Widely expressed in different tissues. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Prohibitin is an evolutionarily conserved protein that is ubiquitously expressed. It is thought to be a negative regulator of cell proliferation and may be a tumor suppressor. Mutations have been linked to sporadic breast cancer. Prohibitin is expressed as two transcripts with varying lengths of 3' untranslated region.
References
Gregory-Bass,R.C., Int. J. Cancer 122 (9), 1923-1930 (2008)
Ross,J.A., J. Biol. Chem. 283 (8), 4699-4713 (2008)
White,J.J., Genomics 11 (1), 228-230 (1991)
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