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C11orf30 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q7Z589 |
| Other Accession | Q8BMB0, Q7ZUV7 |
| Reactivity | Human |
| Predicted | Zebrafish, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 141468 Da |
| Antigen Region | 46-75 aa |
| Gene ID | 56946 |
|---|---|
| Other Names | Protein EMSY, EMSY, C11orf30 |
| Target/Specificity | This C11orf30 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-75 amino acids from the N-terminal region of human C11orf30. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | C11orf30 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EMSY (HGNC:18071) |
|---|---|
| Synonyms | C11orf30 |
| Function | Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). |
| Cellular Location | Nucleus. Note=Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process |
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Provided below are standard protocols that you may find useful for product applications.
Background
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2.
References
?Esparza-Gordillo, J., et al. Nat. Genet. 41(5):596-601(2009)
?Garapaty, S., et al. J. Biol. Chem. 284(12):7542-7552(2009)
?Mavaddat, N., et al. Cancer Epidemiol. Biomarkers Prev. 18(1):255-259(2009)
?Vega, A., et al. Gynecol. Oncol. 112(1):210-214(2009)
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