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DANRE neurog1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O42606 |
| Reactivity | Zebrafish |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22911 Da |
| Antigen Region | 112-138 aa |
| Gene ID | 30239 |
|---|---|
| Other Names | Neurogenin-1, NGN-1, Neurogenic differentiation factor 3, NeuroD3, Neurogenin-related protein 1, neurog1, neurod3, ngn1, ngr1 |
| Target/Specificity | This DANRE neurog1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-138 amino acids from the Central region of DANRE neurog1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DANRE neurog1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | neurog1 |
|---|---|
| Synonyms | neurod3, ngn1, ngr1 |
| Function | Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon-Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons; involved in the specification of dopaminergic progenitor cells. May be involved in maintaining rhombomere boundaries in the hindbrain. |
| Cellular Location | Nucleus. |
| Tissue Location | Embryonic nervous system. Expressed transiently in neurogenic placodes prior to delamination and formation of cranial ganglia. Expressed early (6-somite stage) in Rohon-Beard spinal sensory neurons and later in neural crest-derived dorsal root ganglion neurons At 24 hours post-fertilization (hpf), expressed in specific regions of the brain and spinal cord. In hindbrain, expressed in presumptive neuroblasts adjacent to the rhombomere boundaries. In basal forebrain, expressed in dopaminergic progenitor cells |
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Background
Transcriptional regulator. Activates transcription by binding to the E box-containing promoter (By similarity). Mediates neuronal differentiation. Required for the development of Rohon-Beard spinal sensory neurons and dorsal root ganglion neurons, but not for primary motoneurons or autonomic neurons. Required for development of all cranial ganglia but not associated glial cells. Regulates epiphysial neurogenesis, acting partially redundantly with ascl1a and downstream of flh. Required for the development of basal forebrain dopaminergic neurons; involved in the specification of dopaminergic progenitor cells. May be involved in maintaining rhombomere boundaries in the hindbrain.
References
Blader P., et al. Development 124:4557-4569(1997).
Kim C.-H., et al. Neurosci. Lett. 239:113-116(1997).
Korzh V., et al. Dev. Dyn. 213:92-104(1998).
Thisse B., et al. Submitted (MAR-1997) to the EMBL/GenBank/DDBJ databases.
Cornell R.A., et al. Development 129:2639-2648(2002).
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