Interactive Jak_Stat Signaling Pathway
The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway cascades to transduce cellular signals for development and homeostasis. The JAK-STAT signaling pathway is a critical component of cytokine receptor and growth factor systems regulating growth, survival, differentiation, and activation of the immune system. JAK activation plays a role in specific cellular processes such as cell proliferation, cell migration and apoptosis. Mutational downregulation of the JAK/STAT pathway affects hematopoiesis, immune system development, adipogenesis, and other processes. Upregulation caused by specific mutations contributes to inflammatory disease, erythrocytosis, and cancers, among other disorders.