ABCG4 Antibody (C-Term)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| E |
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Primary Accession | Q9H172 |
Other Accession | NP_071452.2, 64137, 192663 (mouse), 300664 (rat) |
Predicted | Human, Mouse, Rat, Dog |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 71896 Da |
Gene ID | 64137 |
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Other Names | ATP-binding cassette sub-family G member 4, ABCG4, WHITE2 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ABCG4 Antibody (C-Term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ABCG4 (HGNC:13884) |
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Synonyms | WHITE2 |
Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL) (PubMed:15240127, PubMed:33141061). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity). Induces apoptosis in various cells (PubMed:27228027). |
Cellular Location | Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q91WA9}; Multi-pass membrane protein. Endosome membrane {ECO:0000250|UniProtKB:Q91WA9}; Multi- pass membrane protein |
Tissue Location | Expressed specifically in the brain and the eye. |
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Provided below are standard protocols that you may find useful for product applications.
References
ABCG4: a novel human white family ABC-transporter expressed in the brain and eye. Oldfield S, Lowry C, Ruddick J, Lightman S. Biochim Biophys Acta. 2002 Aug 19;1591(1-3):175-9 PMID: 12183068
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