PRMT2 Antibody (internal region)
Peptide-affinity purified goat antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | P55345 |
Other Accession | NP_001526.2, NP_001229793.1, NP_001229794.1, NP_001229795.1, 3275, 15468 (mouse), 499420 (rat) |
Reactivity | Human, Mouse, Rat |
Predicted | Pig, Cow |
Host | Goat |
Clonality | Polyclonal |
Concentration | 0.5 mg/ml |
Isotype | IgG |
Calculated MW | 49042 Da |
Gene ID | 3275 |
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Other Names | Protein arginine N-methyltransferase 2, 2.1.1.-, Histone-arginine N-methyltransferase PRMT2, 2.1.1.125, PRMT2, HMT1, HRMT1L1 |
Format | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PRMT2 Antibody (internal region) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PRMT2 |
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Synonyms | HMT1, HRMT1L1 |
Function | Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)- mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation. |
Cellular Location | [Isoform 1]: Cytoplasm. Nucleus. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. Excluded from nucleolus [Isoform PRMT2Beta]: Cytoplasm. Nucleus. Nucleus, nucleolus [Isoform PRMT2L2]: Cytoplasm. Nucleus Note=Predominantly cytoplasmic |
Tissue Location | Widely expressed. Highly expressed in androgen target organs such as heart, prostate, skeletal muscle, ovary and spinal cord. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This antibody is expected to recognize all reported isoforms (NP_001526.2; NP_001229793.1; NP_001229794.1; NP_001229795.1). Reported variants represent identical protein: NP_001526.2, NP_996845.1
References
A protein arginine N-methyltransferase 1 (PRMT1) and 2 heteromeric interaction increases PRMT1 enzymatic activity. Pak ML, Lakowski TM, Thomas D, Vhuiyan MI, Hüsecken K, Frankel A. Biochemistry. 2011 Sep 27;50(38):8226-40. PMID: 21851090
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