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C21ORF18 antibody - C-terminal region
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB |
|---|---|
| Primary Accession | Q9NVD3 |
| Other Accession | NM_017438, NP_059134 |
| Reactivity | Human, Mouse, Rat, Rabbit, Horse, Bovine, Dog |
| Predicted | Human, Mouse, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 50kDa |
| Gene ID | 54093 |
|---|---|
| Alias Symbol | C21orf18, C21orf27 |
| Other Names | SET domain-containing protein 4, 2.1.1.-, SETD4, C21orf18, C21orf27 |
| Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. |
| Reconstitution & Storage | Add 50 ul of distilled water. Final anti-C21ORF18 antibody concentration is 1 mg/ml in PBS buffer with 2% sucrose. For longer periods of storage, store at 20°C. Avoid repeat freeze-thaw cycles. |
| Precautions | C21ORF18 antibody - C-terminal region is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SETD4 {ECO:0000303|PubMed:24738023, ECO:0000312|HGNC:HGNC:1258} |
|---|---|
| Function | Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins (PubMed:31308046, PubMed:35545041, PubMed:37926288). Via its catalytic activity, regulates many processes, including cell proliferation, cell differentiation, inflammatory response and apoptosis. Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of pro- inflammatory cytokines IL6 and TNF-alpha (By similarity). Through the catalysis of TBK1 monomethylation, may regulate virus-induced interferon signaling. TBK1 monomethylation enhances its interaction with MAVS, STING and IRF3, hence promoting antiviral interferon signaling (PubMed:37926288). Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (PubMed:31308046). In the brain, epigenetically controls quiescence of neural stem cells for sustaining a protected neural stem cell population and maintaining a stem cell reservoir for neurogenesis (By similarity). Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (By similarity). Through the catalysis of XRCC5/Ku70 trimethylation, regulates BAX-mediated apoptosis. SETD4-catalyzed XRCC5 methylation results in XRCC5 translocation to the cytoplasm, where it interacts with BAX, sequestering it from the mitochondria, hence preventing BAX- mediated apoptosis (PubMed:35545041). |
| Cellular Location | Cytoplasm, cytosol. Nucleus |
Research Areas
Citations (0)
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info@abcepta.com, and receive a free "I Love Antibodies" mug.
Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Reymond,A., et al., (2001) Genomics 78 (1-2), 46-54Reconstitution and Storage:For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
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$ 389.00
Cat# AI10689
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