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> home > Products > Primary Antibodies > Antibody Collections > Catalog Updated > SETD4 Antibody (N-term)
SETD4 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NVD3 |
| Other Accession | NP_001007260.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 50416 Da |
| Antigen Region | 14-41 aa |
| Gene ID | 54093 |
|---|---|
| Other Names | SET domain-containing protein 4, 211-, SETD4, C21orf18, C21orf27 |
| Target/Specificity | This SETD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-41 amino acids from the N-terminal region of human SETD4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SETD4 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SETD4 {ECO:0000303|PubMed:24738023, ECO:0000312|HGNC:HGNC:1258} |
|---|---|
| Function | Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins (PubMed:31308046, PubMed:35545041, PubMed:37926288). Via its catalytic activity, regulates many processes, including cell proliferation, cell differentiation, inflammatory response and apoptosis. Regulates the inflammatory response by mediating mono- and dimethylation of 'Lys-4' of histone H3 (H3K4me1 and H3K4me2, respectively), leading to activate the transcription of pro- inflammatory cytokines IL6 and TNF-alpha (By similarity). Through the catalysis of TBK1 monomethylation, may regulate virus-induced interferon signaling. TBK1 monomethylation enhances its interaction with MAVS, STING and IRF3, hence promoting antiviral interferon signaling (PubMed:37926288). Also involved in the regulation of stem cell quiescence by catalyzing the trimethylation of 'Lys-20' of histone H4 (H4K20me3), thereby promoting heterochromatin formation (PubMed:31308046). In the brain, epigenetically controls quiescence of neural stem cells for sustaining a protected neural stem cell population and maintaining a stem cell reservoir for neurogenesis (By similarity). Involved in proliferation, migration, paracrine and myogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) (By similarity). Through the catalysis of XRCC5/Ku70 trimethylation, regulates BAX-mediated apoptosis. SETD4-catalyzed XRCC5 methylation results in XRCC5 translocation to the cytoplasm, where it interacts with BAX, sequestering it from the mitochondria, hence preventing BAX- mediated apoptosis (PubMed:35545041). |
| Cellular Location | Cytoplasm, cytosol. Nucleus |
Research Areas
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
Background
C21orf18 contains 1 SET domain. The exact function is not known.
References
Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :
Reymond, A., et al. Genomics 78 (1-2), 46-54 (2001) :
Watanabe, K., et al. Genomics 52(1):95-100(1998)
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$ 192.50
$ 75.00
Cat# AP18238a
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