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NPTN / SDR1 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q9Y639 |
| Reactivity | Human, Mouse, Rabbit, Hamster, Monkey, Pig, Horse, Bovine, Guinea Pig, Dog |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 44kDa |
| Dilution | IHC-P (15-20 µg/ml) |
| Gene ID | 27020 |
|---|---|
| Other Names | Neuroplastin, Stromal cell-derived receptor 1, SDR-1, NPTN, SDFR1, SDR1 |
| Target/Specificity | Human NPTN. BLAST analysis of the peptide immunogen showed no homology with other human proteins. |
| Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
| Precautions | NPTN / SDR1 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NPTN |
|---|---|
| Synonyms | SDFR1, SDR1 |
| Function | Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed:30190470). Promotes localization of XKR8 at the cell membrane (PubMed:27503893). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P97546}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P97546} |
| Tissue Location | Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level) {ECO:0000269|PubMed:17196182, ECO:0000269|Ref.1} |
| Volume | 100 µl |
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Provided below are standard protocols that you may find useful for product applications.
Background
Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity).
References
Lopez N.D.,et al.Biomed. Res. 20:43-49(1999).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
Totoki Y.,et al.Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
Mural R.J.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
Zhang Z.,et al.Protein Sci. 13:2819-2824(2004).
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