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NPTN Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y639 |
| Other Accession | P97546, P97300, NP_001154835.1, NP_036560.1, NP_001154836.1, NP_059429.1 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 44387 Da |
| Antigen Region | 188-216 aa |
| Gene ID | 27020 |
|---|---|
| Other Names | Neuroplastin, Stromal cell-derived receptor 1, SDR-1, NPTN, SDFR1, SDR1 |
| Target/Specificity | This NPTN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-216 amino acids from the N-terminal region of human NPTN. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | NPTN Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NPTN |
|---|---|
| Synonyms | SDFR1, SDR1 |
| Function | Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed:30190470). Promotes localization of XKR8 at the cell membrane (PubMed:27503893). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P97546}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P97546} |
| Tissue Location | Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level) {ECO:0000269|PubMed:17196182, ECO:0000269|Ref.1} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. [provided by RefSeq].
References
Bernstein, H.G., et al. Brain Res. 1134(1):107-112(2007)
Saito, A., et al. Neurosci. Lett. 411(3):168-173(2007)
Zhang, Z., et al. Protein Sci. 13(10):2819-2824(2004)
Langnaese, K., et al. J. Biol. Chem. 272(2):821-827(1997)
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