CD316 / IGSF8 Antibody (Internal)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P |
---|---|
Primary Accession | Q969P0 |
Reactivity | Human, Rabbit, Monkey, Pig, Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 65kDa |
Dilution | IHC-P (15 µg/ml) |
Gene ID | 93185 |
---|---|
Other Names | Immunoglobulin superfamily member 8, IgSF8, CD81 partner 3, Glu-Trp-Ile EWI motif-containing protein 2, EWI-2, Keratinocytes-associated transmembrane protein 4, KCT-4, LIR-D1, Prostaglandin regulatory-like protein, PGRL, CD316, IGSF8, CD81P3, EWI2, KCT4 |
Target/Specificity | Human IGSF8. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except SIAH2 (53%). |
Reconstitution & Storage | Long term: -70°C; Short term: +4°C |
Precautions | CD316 / IGSF8 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | IGSF8 |
---|---|
Synonyms | CD81P3, EWI2, KCT4 |
Function | May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin-dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain. |
Cellular Location | Cell membrane; Single-pass membrane protein |
Tissue Location | Expressed in brain, kidney, testis, liver and placenta with moderate expression in all other tissues. Detected on a majority of B-cells, T-cells, and natural killer cells but not on monocytes, polynuclear cells and platelets |
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Background
May play a key role in diverse functions ascribed to CD81 and CD9 such as oocytes fertilization or hepatitis C virus function. May regulate proliferation and differentiation of keratinocytes. May be a negative regulator of cell motility: suppresses T-cell mobility coordinately with CD81, associates with CD82 to suppress prostate cancer cell migration, regulates epidermoid cell reaggregation and motility on laminin-5 with CD9 and CD81 as key linkers. May also play a role on integrin- dependent morphology and motility functions. May participate in the regulation of neurite outgrowth and maintenance of the neural network in the adult brain.
References
Stipp C.S.,et al.J. Biol. Chem. 276:40545-40554(2001).
Charrin S.,et al.Biochem. J. 373:409-421(2003).
Bonkobara M.,et al.Br. J. Dermatol. 148:654-664(2003).
Zhang W.,et al.Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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