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15-PGDH / HPGD Antibody (aa205-266)
Rabbit Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, IHC-P, ICC |
|---|---|
| Primary Accession | P15428 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 29kDa |
| Dilution | ICC (1:100-1:1000), IHC-P (5 µg/ml), WB (1:500-1:3000) |
| Gene ID | 3248 |
|---|---|
| Other Names | 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 15-PGDH, 1.1.1.141, Prostaglandin dehydrogenase 1, HPGD, PGDH1 |
| Target/Specificity | Human 15-PGDH / HPGD |
| Reconstitution & Storage | Keep as concentrated solution. Aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles. |
| Precautions | 15-PGDH / HPGD Antibody (aa205-266) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HPGD (HGNC:5154) |
|---|---|
| Synonyms | PGDH1, SDR36C1 |
| Function | Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (PubMed:10837478, PubMed:16757471, PubMed:16828555, PubMed:21916491, PubMed:25586183, PubMed:8086429). Decreases the levels of the pro- proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression (PubMed:15574495, PubMed:25586183). Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (PubMed:16757471, PubMed:22844113). |
| Cellular Location | Cytoplasm. |
| Tissue Location | Detected in colon epithelium (at protein level). |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Prostaglandin inactivation. Contributes to the regulation of events that are under the control of prostaglandin levels. Catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form 15-oxo-lipoxin A4. Inhibits in vivo proliferation of colon cancer cells.
References
Krook M.,et al.Biochemistry 29:738-743(1990).
Ensor C.M.,et al.J. Biol. Chem. 265:14888-14891(1990).
Pichaud F.,et al.Gene 162:319-322(1995).
Delage-Mourroux R.,et al.Gene 188:143-148(1997).
Ota T.,et al.Nat. Genet. 36:40-45(2004).
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