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Anti-BEST2 / Bestrophin-2 Antibody (Internal)

Rabbit Anti Human Polyclonal Antibody

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immuno electron microscopy
  • EIA=Enzyme Immunoassay
IHC-P
Primary Accession Q8NFU1
Predicted Human, Mouse, Rat, Hamster, Monkey, Pig, Bovine
Host Rabbit
Clonality Polyclonal
Calculated MW 57139 Da
Dilution IHC-P (2.5 - 5 µg/ml)
Additional Information
Gene ID 54831
Alias Symbol BEST2
Other Names BEST2, Bestrophin-2, Bestrophin 2, Hbest2, VMD2-like gene 1, VMD2L1
Target/Specificity Human BEST2 / Bestrophin-2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except BEST3 (59%).
Reconstitution & Storage Immunoaffinity purified
PrecautionsAnti-BEST2 / Bestrophin-2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name BEST2 (HGNC:17107)
Synonyms VMD2L1
Function Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+) (PubMed:11904445, PubMed:18400985, PubMed:32251414, PubMed:35789156, PubMed:36289327). Transports a large specter of anions, namely mediates the movement of chloride, L-glutamate and iodide (PubMed:11904445, PubMed:18400985, PubMed:32251414, PubMed:35789156, PubMed:36289327). Calcium-binding triggers the dilation of the aperture, but calcium- dependent gating is only effective when the size of the passing anion is bigger than the closed aperture (By similarity). Mediates the calcium-activated hydrogencarbonate movement and participates in colonic hydrogencarbonate secretion concomitant with mucin secretion (By similarity). In non-pigmented epithelium (NPE), mediates the efflux of intracellular L-glutamate; binding of intracellular L-glutamate activates and open both the neck and the aperture of the channel, leading to L-glutamate exit promoting chloride influx movement from the extracellular side in trans (PubMed:36289327). Also exhibits a directional permeability for intracellular glutamine, in a similar manner as for L-glutamate (PubMed:36289327).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:E1BF86}; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein
Tissue Location Mainly confined to the retinal pigment epithelium (PubMed:12032738). Expressed in colon (PubMed:12032738, PubMed:20407206).
Research Areas
Citations (0)
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$ 467.50
Cat# ALS17574
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