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> home > Products > Primary Antibodies > Signal Transduction > Anti-BEST2 / Bestrophin-2 Antibody (Internal)
Anti-BEST2 / Bestrophin-2 Antibody (Internal)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P |
|---|---|
| Primary Accession | Q8NFU1 |
| Predicted | Human, Mouse, Rat, Hamster, Monkey, Pig, Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Calculated MW | 57139 Da |
| Dilution | IHC-P (2.5 - 5 µg/ml) |
| Gene ID | 54831 |
|---|---|
| Alias Symbol | BEST2 |
| Other Names | BEST2, Bestrophin-2, Bestrophin 2, Hbest2, VMD2-like gene 1, VMD2L1 |
| Target/Specificity | Human BEST2 / Bestrophin-2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except BEST3 (59%). |
| Reconstitution & Storage | Immunoaffinity purified |
| Precautions | Anti-BEST2 / Bestrophin-2 Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BEST2 (HGNC:17107) |
|---|---|
| Synonyms | VMD2L1 |
| Function | Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+) (PubMed:11904445, PubMed:18400985, PubMed:32251414, PubMed:35789156, PubMed:36289327). Transports a large specter of anions, namely mediates the movement of chloride, L-glutamate and iodide (PubMed:11904445, PubMed:18400985, PubMed:32251414, PubMed:35789156, PubMed:36289327). Calcium-binding triggers the dilation of the aperture, but calcium- dependent gating is only effective when the size of the passing anion is bigger than the closed aperture (By similarity). Mediates the calcium-activated hydrogencarbonate movement and participates in colonic hydrogencarbonate secretion concomitant with mucin secretion (By similarity). In non-pigmented epithelium (NPE), mediates the efflux of intracellular L-glutamate; binding of intracellular L-glutamate activates and open both the neck and the aperture of the channel, leading to L-glutamate exit promoting chloride influx movement from the extracellular side in trans (PubMed:36289327). Also exhibits a directional permeability for intracellular glutamine, in a similar manner as for L-glutamate (PubMed:36289327). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:E1BF86}; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein |
| Tissue Location | Mainly confined to the retinal pigment epithelium (PubMed:12032738). Expressed in colon (PubMed:12032738, PubMed:20407206). |
Research Areas
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$ 467.50
Cat# ALS17574
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