Anti-EMD / Emerin Antibody (N-Terminus)
Rabbit Anti Human Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, FC |
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Primary Accession | P50402 |
Predicted | Human |
Host | Rabbit |
Clonality | Polyclonal |
Calculated MW | 28994 Da |
Dilution | Flo (1:10 - 1:50), IHC-P (5 µg/ml), WB (1:1000) |
Gene ID | 2010 |
---|---|
Alias Symbol | EMD |
Other Names | EMD, EDMD, Emerin, LEM domain containing 5, LEMD5, STA |
Reconstitution & Storage | Ammonium sulfate precipitation |
Precautions | Anti-EMD / Emerin Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | EMD |
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Synonyms | EDMD, STA |
Function | Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta- catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1- dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non- farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells (PubMed:32923640). EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. |
Cellular Location | Nucleus inner membrane; Single-pass membrane protein; Nucleoplasmic side. Nucleus outer membrane. Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus |
Tissue Location | Skeletal muscle, heart, colon, testis, ovary and pancreas |
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