|Application ||WB, E|
|Other Accession||NP_150639.1, NP_653288.1|
|Calculated MW||120173 Da|
|Other Names||NACHT, LRR and PYD domains-containing protein 12, Monarch-1, PYRIN-containing APAF1-like protein 7, Regulated by nitric oxide, NLRP12, NALP12, PYPAF7, RNO|
|Target/Specificity||This NLRP12 monoclonal antibody is generated from mouse immunized with NLRP12 recombinant protein.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NLRP12 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||NALP12, PYPAF7, RNO|
|Function||May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.|
|Tissue Location||Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Alternatively spliced transcript variants encoding distinct isoforms have been described but the full-length nature of some of these has not been determined.
Bailey, S.D., et al. Diabetes Care (2010) In press : Cummings, J.R., et al. Tissue Antigens 76(1):48-56(2010) Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009) Fahy, R.J., et al. Am. J. Respir. Crit. Care Med. 177(9):983-988(2008) Jeru, I., et al. Proc. Natl. Acad. Sci. U.S.A. 105(5):1614-1619(2008)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.