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CDC25C Antibody
Mouse Monoclonal Antibody (Mab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P30307 |
| Other Accession | NP_001781.2, NP_073720.1 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1,k |
| Clone/Animal Names | 233CT9.6.6 |
| Calculated MW | 53365 Da |
| Gene ID | 995 |
|---|---|
| Other Names | M-phase inducer phosphatase 3, Dual specificity phosphatase Cdc25C, CDC25C |
| Target/Specificity | This CDC25C monoclonal antibody is generated from mouse immunized with CDC25C recombinant protein. |
| Dilution | WB~~1:100 E~~Use at an assay dependent concentration. |
| Format | Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, followed by dialysis against PBS. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CDC25C Antibody is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CDC25C |
|---|---|
| Function | Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle (PubMed:8119945). When phosphorylated, highly effective in activating G2 cells into prophase (PubMed:8119945). Directly dephosphorylates CDK1 and activates its kinase activity (PubMed:8119945). |
| Cellular Location | Nucleus |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq].
References
Moon, D.O., et al. Oncol. Rep. 24(1):271-276(2010) Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010) Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press : Franckhauser, C., et al. PLoS ONE 5 (7), E11798 (2010) : Wang, Z., et al. BMC Cancer 10, 233 (2010) :
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